Annexon To Present Pivotal Data On First Potential Targeted Therapy For Guillain-Barré Syndrome And Showcases New GBS Education Campaign At AAN 2025 Annual Meeting

Oral Presentation Features Phase 3 Data Showing Rapid Recovery and Durable Benefit of Tanruprubart (formerly ANX005) on Clinically Meaningful Measures across Multiple Stages of GBS

Disease Education Campaign for Healthcare Providers called Move GBS Forward™ (MoveGBSForward.com) Highlights

Life-altering Impact of GBS

BRISBANE, Calif., April 08, 2025 (GLOBE NEWSWIRE) -- Annexon, Inc. (NASDAQ:ANNX), a biopharmaceutical company advancing a late-stage clinical platform of novel therapies for people living with devastating classical complement-mediated neuroinflammatory diseases of the body, brain, and eye, today presented data for its late-stage targeted therapy for GBS and showcased new disease education activities at the AAN Annual Meeting taking place April 5–9, 2025, in San Diego, California. An oral presentation today during the "Clinical Trials Plenary" session featured results of the tanruprubart (formerly ANX005) Phase 3 placebo-controlled trial reinforcing its rapid and durable clinical benefits for patients with GBS. A replay of the session is available to AAN registrants.

GBS is a neuromuscular emergency that affects at least 150,000 people worldwide each year, with no FDA-approved therapies. The rare autoimmune disease is characterized by rapidly progressing and severe weakness that can lead to complete paralysis, often requiring intensive care and mechanical ventilation.

Tanruprubart is a first-in-kind monoclonal antibody designed to block C1q, the initiating molecule of the classical complement cascade. With a single infusion, tanruprubart halts ongoing neuroinflammation and nerve damage in the acute phase of GBS to improve and expedite overall recovery.